Drug Metabolism

The following represents MRI's capabilities in drug metabolism research.

• Pharmacokinetics, metabolism,
  and disposition
• Bioanalytical methods development
• DNA and protein binding
• Biochemical methods
• Metabolite identification
• Tissue residue levels
• Bioequivalency

Pharmacokinetics, Metabolism, and Disposition

World renowned for providing high quality, timely contract services to both the human and veterinary pharmaceutical industries, MRI assists clients in development efforts from discovery through clinical trials. We share a common goal with our clients to deliver high quality, cost-effective, and responsive services.

Our highly trained staff offer innovative, quality research in accordance with internationally accepted Good Laboratory Practice regulations. Quality assurance at MRI is designed to ensure that work meets both client-specific QA and federal regulations.

Contact:

Thomas Grant,
Ph.D.
Director, Business Development
(816) 360-5328

Pharmacokinetic and metabolism data are an essential part of the comprehensive safety evaluation of a new chemical entity. We offer extensive experience in studies of the fate of radiolabeled (e.g., 14C, 3H, 125I) and non-labeled molecules, including:

Absorption

• Blood/plasma pharmacokinetics
• Dose linearity
• Bioavailability/bioequivalence
• Toxicokinetics
• Intestinal absorption

Distribution

• Tissue distribution
• Bioaccumulation/bioretention
• Plasma protein/blood cell binding
• Melanin binding

Metabolism

• Metabolite profiling
• Metabolite characterization and identification
• Rates of biotransformation
• Residue analysis

Excretion

• Routes and rates of excretion

Routes of Administration

• Oral
• Intravenous (bolus)
• Intravenous (continuous infusion)
• Subcutaneous
• Intramuscular
• Dermal

Pharmacokinetic Analysis

We analyze data using the optimum pharmacokinetic model to define pharmacokinetic parameters of a compound and/or its metabolites. MRI also can perform model dependent and independent pharmacokinetic analyses.

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Bioanalytical Methods Development

MRI routinely develops and validates specific analytical methods for the measurement of candidate drugs and metabolites in biological matrices, using a comprehensive range of chromatographic and mass spectrometric methods. We also develop immunoassay methods, such as RIA and ELISA, and can prepare novel antibodies for such methods. Method validation studies include evaluation of:

• Accuracy
• Linearity
• Ruggedness
• Precision
• Specificity
• Limit of quantitation

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