Toxicology

MRI has the staff, facilities, quality program, and data management systems to conduct a variety of routine and customized toxicology studies. Following are several areas of MRI expertise in toxicology.

• In-vivo and in-vitro methods
• Preclinical safety assessment studies
• GLP and preliminary (non-GLP) studies.
• Acute and sub-chronic studies
• Repeated dose studies
• Multiple routes of exposure
• Toxicokinetics and pharmacokinetics
• Novel feeding and palatability studies
• Clinical chemistry and histopathology
• Evaluation of pathogens requiring containment (ABSL-2/3)
• Customized study designs and alternative models

MRI is equipped to address multiple routes of exposure. Capabilities include the following:

Contact:

Thomas Grant,
Ph.D.
Director, Business Development
(816) 360-5328

Toxicokinetics and pharmacokinetics

MRI is uniquely qualified to provide all aspects of toxicokinetic and pharmacokinetic (TK/PK) studies, including development of bioanalytical methods, test system exposure, and analysis and interpretation of kinetic data. MRI takes an integrated approach to the design and conduct of TK/PK studies, using its resources and expertise in both Bioanalytical Chemistry and Toxicology. This approach allows MRI to customize every phase of a kinetic study and accommodate even the most challenging of test compounds.

Novel feeding and palatability studies

MRI is at the forefront of the scientific community in developing alternative methodology to incorporate test compounds into dietary formulations. This technology includes microencapsulation, and provides a dietary route of exposure to chemicals that previously were administered only through oral gavage. MRI has successfully microencapsulated a variety of test compounds with varying chemical properties. Following encapsulation, MRI has conducted palatability studies in a variety of species to ensure that feed additives do not affect normal food consumption.

Studies requiring specialized containment

MRI can accommodate test materials requiring containment conditions more restrictive than conventional vivarium facilities. MRI has both ABSL-2 and ABSL-3 laboratories. With these laboratories, MRI is able to conduct safety and toxicology studies in test systems infected with biological agents.

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