Chemical and Materials Synthesis

MRI is fully equipped to provide research and product development of chemicals, from milligram to kilogram lots. We provide a diversity of high quality, chemistry-related services such as custom synthesis, process discovery, process improvement, trace impurity isolation/identification, analytical standard preparation, mechanistic studies, and literature surveys.

Capabilities

• Custom synthesis
• Inert atmosphere techniques
• Thin films/MOCVD precursor design
• Photochemical/electrochemical synthesis
• Process optimization
• Radiolabeled compound synthesis
• Trace impurity isolation and identification
• Mechanistic studies
• Literature survey, review, and evaluation

Custom Synthesis

Contact:

John S. Stanley,
Ph.D.
Group Vice President,
Business Development
(816) 753-7600,
ext. 1160

MRI can prepare organic, inorganic, organometallic, polymer, and bioorganic
compounds according to procedures supplied by the client, available in the
technical literature, or devised by our staff. Our expertise also includes
synthetic method development and polymer design and synthesis, including:

• Biocompatible polymers and resins
• High temperature polymers
• Patented dental resins and adhesives
• Protective and sorbent coatings

back to top

Inert Atmosphere Techniques

Air- and/or moisture-sensitive materials can be routinely handled using
glove box, vacuum line, and double-manifold (Schlenk) line techniques.

back to top

Thin Films/MOCVD Precursor Design

MRI has cold-wall (inductively heated) reactors, with infrared thermometer and temperature controllers; and hot-wall reactors, with thermocouple controllers.

back to top

Photochemical/Electrochemical Synthesis

MRI has Heraeus UV-RS-4 high-pressure Hg-lamp reactors (1-liter working volume); EG&G PAR research electrochemical instrumentation (Model 273A).

back to top

Process Optimization

Once synthesis routes have been identified and developed through process
discovery, we can evaluate the process further by using the tools of statistical
experimental design. MRI emphasizes improved yields, simplified handling,
and increased safety.

back to top

Radiolabeled Compound Synthesis

MRI combines microsynthesis techniques with selected radiolabeled source
compounds to synthesize unique and/or complex molecules.

back to top

Trace Impurity Isolation and Identification

Components of interest can be isolated by the most appropriate technique,
including HPLC, MPLC, GC, and flash chromatography. Spectroscopic
techniques for identification include NMR (1H, 13C, 19F, 31P, etc.), FT-IR,
UV-Vis, MS, GC-MS, LC-MS, and LC-MS/MS.

back to top

Mechanistic Studies

Experiments can be conducted to investigate possible mechanisms of
chemical reactions.

back to top

Literature Survey, Review, and Evaluation

MRI's Patterson Library has extensive research holdings. In addition, the library staff and key technical research staff have on-line literature search and document
retrieval capabilities. Technical literature searches can be conducted, references can be reviewed and evaluated, and findings or recommendations reported.

back to top